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Cholesterol Support is designed to support normal cholesterol and triglyceride levels for natural heart health
Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membranes. It is the principal sterol synthesized by all animals. Within the cell membrane, cholesterol also functions in intracellular transport, cell signaling, and nerve conduction. Cholesterol is essential for the structure and function of invaginated caveolae and clathrin-coated pits, including caveola-dependent and clathrin-dependent endocytosis. Within cells, cholesterol is also a precursor molecule for several biochemical pathways. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid, and vitamin D. It is the precursor molecule for the synthesis of vitamin D in the calcium metabolism and all steroid hormones include cortisol, aldosterone, progesterone, estrogens, testosterone, and their derivatives.
Cholesterol regulates the biological process of substrate presentation (activates a protein) and the enzymes that use substrate presentation as a mechanism of their activation. Specifically, cholesterol allows the cell membrane to stay flexible and allow lipids to pass through. Without cholesterol, cell walls are not properly shaped, which can cause problems with the body’s overall metabolism. Cholesterol also assists the transportation and communication between cells. Cholesterol also helps in the formation of your memories and is vital for neurological function.
Cholesterol is a signaling molecule. In human health, its effects are most notable in inflammation and metabolic syndrome. At the molecular level, cholesterol primarily signals by regulating lipid rafts and raft-associated membrane protein translocation. Cholesterol is one of three major classes of lipids that all animal cells use to construct their membranes and is thus manufactured by all animal cells. Plant cells do manufacture cholesterol but in rather small quantities. Since cholesterol is insoluble in water, it is transported in the blood plasma within protein particles (lipoproteins). Lipoproteins are classified by their density: very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). All the lipoproteins carry cholesterol, but elevated levels of the lipoproteins other than HDL (termed non-HDL cholesterol), particularly LDL-cholesterol, are associated with an increased risk of atherosclerosis and coronary heart disease. HDL cholesterol is known as the "good" cholesterol, so the higher the HDL cholesterol the better. Lowering LDL (low-density lipoprotein), or the "bad" cholesterol, and raising HDL cholesterol is a great way to reduce the risk of heart disease. If the body has more LDL cholesterol than it needs, the excess keeps circulating in the bloodstream.
Cholesterol is measured in milligrams per deciliter (mg/dL) of blood in the United States and some other countries. Cholesterol is measured as millimoles per liter of blood (mmol/Ll) in the United Kingdom, Canada, and most European countries. In the UK, for healthy adults, upper limits of total cholesterol of 5 mmol/L, and low-density lipoprotein cholesterol (LDL) of 3 mmol/L. For people at high risk of cardiovascular disease, the recommended limit for total cholesterol is 4 mmol/L and 2 mmol/L for LDL. In the United States, total cholesterol of less than 200 mg/dL as “desirable,” 200 to 239 mg/dL as “borderline high,” and 240 mg/dL or more as “high”.
A human male weighing 68 kg (150 lb) normally synthesizes about 1 gram (1,000 mg) of cholesterol per day, and his body contains about 35 g, mostly contained within the cell membranes. Typical daily cholesterol dietary intake for a man in the United States is 307 mg.
Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood. Higher levels of total cholesterol increase the risk of cardiovascular disease, particularly coronary heart disease. Levels of LDL or non-HDL cholesterol both predict future coronary heart disease. Avoiding trans fats and include polyunsaturated fats are recommended dietary measures to reduce total blood cholesterol and LDL in adults. About 34 million adults in the United States have high blood cholesterol.
Inflammation-induced by cholesterol loading into immune cells causes heart disease. During an inflammatory response, cholesterol is loaded into immune cells including macrophages. The cholesterol is a signal that activates cytokine production and other inflammatory responses. Cholesterol's role in inflammation is central to many diseases.
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