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Nitric oxide is a signaling molecule involved in many physiological and pathological processes. It is a powerful vasodilator with a half-life of a few seconds in the blood. It plays a critical role in regulating blood flow in your body. Low levels of nitric oxide production are typically due to ischemic damage in the liver. While you can’t consume nitric oxide directly, you can take supplements that increase its production inside your body.
Supplements that increase nitric oxide levels can help improve your exercise performance, increase your strength, and even fight erectile dysfunction. Nitric oxide supplements promote vasodilation and help the body to deliver precious nutrients to the muscle cells and so improve sports performance.
During physical activity, there’s an increase in cardiac output and blood flow redistribution to muscle fibers. As you exercise, muscles become oxygen-depleted. In the absence of oxygen, the body begins to produce lactic acid which will eventually lead to muscle fatigue – to the extent that you can exercise no more. Nitric oxide reduces the amount of lactic acid produced during exercise and extends the amount of time until exhaustion. By speeding up the delivery of oxygen and nutrients to the muscles under stress, nitric oxide improves their response to exercise and so increases sports performance.
Arginine HCL (Arginine Hydrochloride) is the hydrochloride salt form of arginine, an essential amino acid in juvenile humans. It is a synthetically manufactured form of arginine that combines the amino acid with a hydrogen chloride molecule. Hydrogen chloride is combined with arginine to make the supplement more palatable and to enhance its absorption by the digestive system.
One of the main effects of arginine is that it causes vasodilation or an increase in the diameter of blood vessels. Arginine accomplishes this by stimulating the smooth muscle endothelial cells that line the blood vessels to produce a compound called nitric oxide. Nitric oxide stimulates blood vessels to relax and expand, increasing the flow of blood and oxygen to the muscles during high-intensity exercise. An increase in blood flow and oxygen delivery during exercise may enhance performance, allowing muscles to produce more strength and delaying the onset of exercise-induced fatigue.
Arginine, also known as L-arginine, apart from being a component of proteins, stimulates the release of hormones such as insulin, glucagon, prolactin, and growth hormone. Arginine is known to be a nitric oxide precursor which can improve nitric oxide serum levels. L-arginine is broken down into nitric oxide (NO) in various tissues. Depending on where it’s produced, nitric oxide plays a critical role in regulating diverse functions in the body.
One of the main effects of arginine supplementation for bodybuilders is its ability to stimulate growth hormone production. This is mainly due to arginine’s ability to suppress somatostatin secretion, a hormone that inhibits growth hormone. Growth hormones are responsible for cell and tissue growth, making them absolutely essential for muscle growth.
Arginine also plays a critical role in maintaining normal blood pressure, heart function, and immunity. These functions are mediated through the production of nitric oxide. Arginine is broken down into ornithine and creatine. Ornithine is essential for cell growth and division, while creatine is important for muscle contraction.
Arginine alpha-ketoglutarate (AAKG) is a modified version of the amino acid arginine. Arginine in combination with alpha-ketoglutarate (as arginine alpha-ketoglutarate [AAKG]) used by athletes and bodybuilders to improve sports performance, reduce muscle fatigue, and enhance recovery. Arginine alpha-ketoglutarate is formed when two arginine molecules combine with one molecule of alpha-ketoglutarate.
Alpha-ketoglutarate is an intermediate compound in the series of reactions that produce energy for the body. It is the source of the amino acids glutamate and glutamine. Glutamate is the main excitatory neurotransmitter in the brain and can increase bone formation. Glutamine is the main source of energy for cell division. Glutamine enhances protein, muscle development, and immune function. Alpha-ketoglutarate also regulates amino acid synthesis, energy production, and the formation of free radicals. It functions as a messenger molecule in many chemical reactions in the body. Alpha-ketoglutarate enhances bone formation. It regulates the synthesis of collagen possibly by increasing the number of molecules available for synthesis. Collagen is a significant component of bone tissue.
The combination of alpha-ketoglutarate and arginine improves the stability of arginine. This is supposed to improve its performance-enhancing abilities and its role in energy production.
Arginine ketoisocaproate (AKIC) boosts nitric oxide production leading to improved endurance and recovery time. Alpha-ketoisocaproic acid (KIC), the ketoacid of leucine, has been shown to enhance moderate- and high-intensity exercise performance when consumed in combination with L-arginine (AKIC). Arginine ketoisocaproate(AKIC) aids in the removal of ammonia from your body during workouts. The liver is capable of converting KIC to ketone bodies, thus increasing the potential energy supply during exercise. Additionally, KIC is readily aminated to leucine, in a variety of tissues including skeletal muscle, which may ultimately decrease fatigue and preserve skeletal muscle force production during intense exercise. KIC potentially reduces skeletal muscle NH3 concentrations alter anaerobic energetics and attenuate exercise-induced muscle damage.
OKG (ornithine alpha-ketoglutarate) is an ionic salt made up of one molecule ornithine and two molecules of alpha-ketoglutarate. OKG is an amino acid complex composed of ornithine and ketoglutaric Acid shows incredible promise stimulating muscle repair, energy, and strength. OKG supplements have been shown to promote growth hormone and insulin secretion with anabolic effects. It is commonly taken by bodybuilders and athletes to help with muscle growth, endurance, and recovery.
Ornithine is the precursor of citrulline, glutamic acid, and proline. Ornithine is formed when arginine is altered by the enzyme arginase. Ornithine is a powerful stimulator of growth hormone and insulin production by the pituitary gland. When combined with arginine and carnitine, it helps release a hormone that metabolizes excess body fat helping to reduce arterial fatty plaque deposits. It is necessary for the immune system and liver function. Ornithine has also been successfully used to detoxify ammonia and promote healing. Studies show that ornithine and alpha-ketoglutarate modify protein metabolism in healthy individuals.
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